RORa PROMOTING THE INDUCTION OF Bmal1 EXPRESSION

摘要

It is intended to clarify the undisclosed part of the mechanism controlling the circadian rhythm. It is newly found out that RORa (retinoic acid binding-receptor alpha, the same applies hereinafter) promotes the induction of Bmal1 expression and that the induction of Bmal1 expression is promoted under hypoxic conditions. These facts strongly suggest the presence of the mechanism controlling the circadian rhythm wherein, when RORa expression is promoted under hypoxic conditions etc., the induction of Bmal1 expression is promoted and the promotion of the induction of Bmal1 expression promotes the binding of BMAL1 to CLOCK to thereby promote the induction of the expression of the Per gene or the Cry gene. Accordingly, the above findings are likely applicable to agents for regulating jet lag and anticancer drugs.