Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors

摘要

This invention is directed to a compound of Formula I;
or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and X are as defined herein. The compounds of Formula I are useful as receptor tyrosine kinase (RTK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases.

主权项

1. A compound represented by Formula I, its enantiomers, diastereoisomers, or a pharmaceutically acceptable salt thereof:wherein:
R1 is hydrogen; X is R2 is benzothiophene; R3 is phenyl, optionally substituted with methyl, trifluoromethyl, fluoro, or chloro; R4 is hydrogen or C1-C8 alkyl optionally substituted with hydroxyl.