NOVEL ANIMAL MODELS FOR EVALUATING PHARMACEUTICAL COMPOUNDS

摘要

The application relates to methods for determining a parameter such as toxicity and pharmacokinetic behavior for a pharmaceutical compound against a disease or disorder. The test animals being used are non-human animals not suffering from or is not showing symptoms or signs of the disorder and which do not provoke an immune response against said pharmaceutical compound. These animals are obtainable by administration of a peptide comprising an oxidoreductase motif further comprising an NKT peptide epitope or an MCH class II T cell epitope of said pharmaceutical compound, wherein said motif and said epitope are separated by a linker of between 0 and 4 amino acids.

主权项

1. A method for determining a parameter of a pharmaceutical compound against a disease or disorder, comprising the steps of:
providing a non-human animal which is not suffering from or is not showing symptoms or signs of said disease or disorder and which does not provoke an immune response against said pharmaceutical compound, whereby the animal is obtainable by administration of a peptide comprising an oxidoreductase motif with the sequence [CTS]-x-x-C [SEQ ID NO: 8] or [C]-x-x-[CST] [SEQ ID NO: 9] and further comprising an NKT peptide epitope or an MCH class II T cell epitope of said pharmaceutical compound, wherein said motif and said epitope are separated by a linker of between 0 and 4 amino acids, administering said pharmaceutical compound to the non-human animal, measuring a parameter of said pharmaceutical compound in the non-human animal.