ORGAN CHAMBER FOR EXSANGUINOUS METABOLIC SUPPORT SYSTEM

摘要

An exsanguinous metabolic support system for maintaining an organ (40) or tissue at a near normal metabolic rate is disclosed. The system employs an organ chamber (32) comprising a container (33) and a support member (36) adapted to inhibit movement of the organ (40) within the container (33) during perfusion and/or transport. The organ chamber (32) additionally comprises a conduit (43) for receiving venous outflow of perfusion solution and preventing its contact with the outer surfaces of the organ (40). A conduit (47) for receiving organ product enables the collection of organ product from a functional organ (40) during perfusion. Use of the organ chamber (32) supports de novo or continued synthesis of constituents necessary for long-term maintenance of organs for transplantation, for resuscitation and active repair of organs having sustained warm ischemic damage, and for transportation of isolated organs is also disclosed.