USE OF SPLA2 ACTIVITY FOR THE DIAGNOSIS OF A CARDIOVASCULAR EVENT

摘要

The present invention relates a method for determining an increased risk of mortality or of a cardiac and/or vascular event in a patient, comprising: - determining the sPLA2 activity of said patient as a first risk marker - d etermining at least the value of a second risk marker chosen among CRP level , IgM IC of apo B 100 level or IgM MDA-LDL level - determining the ratio (od ds ratio) between the value of the sPLA2 activity and the value of the secon d risk marker and comparing it to a predetermined odds ratio, said odds rati o compared to said predetermined odds ratio being indicative of an increased risk of mortality or of a cardiac and /or vascular event. The present inven tion further relates a new micro method adaptation for automated fluorimetri c measurement of serum secretory phospholipase A2.