DIHYDROPYRIDAZINE, TETRAHYDROPYRIDINE, CHROMANONE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS HEAT-SHOCK PROTEIN 90 INHIBITORS

摘要

Disclosed are compounds and pharmaceutically acceptable salts of Formula (I), wherein A, Q<SUB>1</SUB>, Q<SUB>2</SUB>, Q<SUB>3</SUB>, R<SUB>3</SUB>, and R<SUB>4</SUB> are as defined herein. Compounds of Formula (I) are heat-shock protein 90 (HSP-90) inhibitors, useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.