发明名称 |
Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
摘要 |
This invention relates to substituted 4-pyridones of formula 1;
and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases. |
申请公布号 |
US9346794(B1) |
申请公布日期 |
2016.05.24 |
申请号 |
US201514981999 |
申请日期 |
2015.12.29 |
申请人 |
Boehringer Ingelheim International GmbH |
发明人 |
Oost Thorsten;Fiegen Dennis;Gnamm Christian |
分类号 |
A61K31/54;A61K31/50;A61K31/501;A61K38/00;A61P11/06;A61P17/00;A61P29/00;C07D215/00;C07D213/62;C07D417/04;C07D213/82;C07D401/04;C07D413/04;C07D405/04 |
主分类号 |
A61K31/54 |
代理机构 |
|
代理人 |
Morris Michael P.;Lazer Edward S. |
主权项 |
1. A compound of formula 1 wherein A is phenyl or pyridinyl; R1a is R1a.1 is C1-4-alkyl-;R1a.2 is NC—; R1b is H; R2 is C1-6-alkyl or a residue selected from the group consisting of C3-6-cycloalkyl-, phenyl-C1-4-alkyl- and a five- or six-membered, aromatic heteroring containing one or two nitrogen atoms, each of the above rings optionally substituted with C1-4-alkyl-, halogen or NC—; R3 is methyl; R4 is phenyl, a five- or six-membered, aromatic ring containing one or two nitrogen atom, each ring optionally substituted with one or two residues selected independently from each other from the group consisting of C1-4-alkyl-, halogen or C1-4-haloalkyl-; R5 is H; R6 is H; R7 is H; or a pharmaceutically acceptable salt thereof. |
地址 |
Ingelheim am Rhein DE |