TRANSDUCIBLE MATERIALS FOR CELL REPROGRAMMING

摘要

The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the sample. In particular, the present inventions are directed to transducible materials that are capable of transducing into the nuclei and have enhanced retention in the nuclei of the biological sample. The present inventions also are directed to methods of reprogramming a biological sample or treating diseases using the transducible compositions thereof.

主权项

1. A transducible material comprising an isolated polypeptide capable of transducing and retaining in a cell nucleus, said isolated polypeptide comprising an effector domain, wherein the effector domain comprises an amino acid sequence mutated from a nuclear export signal (NES).