发明名称 |
Broad spectrum antibiotic compounds and use thereof |
摘要 |
The discovery of a non-ribosomal peptide synthetase (NRPS) gene cluster in the genome of Clostridium thermocellum that produces a secondary metabolite that is assembled outside of the host membrane is described. Also described is the identification of homologous NRPS gene clusters from several additional microorganisms. The secondary metabolites produced by the NRPS gene clusters exhibit broad spectrum antibiotic activity. Thus, antibiotic compounds produced by the NRPS gene clusters, and analogs thereof, their use for inhibiting bacterial growth, and methods of making the antibiotic compounds are described. |
申请公布号 |
US9382294(B2) |
申请公布日期 |
2016.07.05 |
申请号 |
US201414771710 |
申请日期 |
2014.02.28 |
申请人 |
Los Alamos National Security, LLC |
发明人 |
Koglin Alexander;Strieker Matthias |
分类号 |
C07H19/02;C07H17/00;A61K38/00;C07K9/00 |
主分类号 |
C07H19/02 |
代理机构 |
Klarquist Sparkman, LLP |
代理人 |
Klarquist Sparkman, LLP |
主权项 |
1. A compound according to Formula I:where Y is C1-C10 alkyl, and Z is hydrogen or a monosaccharide. |
地址 |
Los Alamos NM US |