| 主权项 |
1. A compound of the following formula Ior a pharmaceutically acceptable salt or solvate thereof, wherein:
R1 is H, C1-20alkyl, C3-6cycloalkyl, C2-4alkenyl, C2-4alkynyl, C1-4heteroalkyl, aryl, heteroaryl, Het1, Het2, C(═O)C1-4alkyl, C(═O)OH, C(═O)OC1-4alkyl, (CH2)mC(═O)OH,(CH2)mC(═O)C1-4alkyl, (CH2)mC(═O)OC1-4alkyl, NH2, NHC1-4alkyl, N(C1-4alkyl)2N(C1-4alkyl)(aryl), OC1-4alkyl, SC1-4alkyl, (CH2)mC3-6cycloalkyl, (CH2)mC(═O)-aryl, or (CH2)mC(═O)-Het1; m is 0, 1, or 2; R2 is selected from H, C1-20alkyl, C3-6cycloalkyl, C2-4alkenyl, C2-4alkynyl, C1-20heteroalkyl, aryl, heteroaryl, [3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one-5-yl]methyl, [3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one-5-yl]methyl, [3(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridine-3-yl)phenyl)-oxazolidin-2-one-5-yl]methyl, [3-(3-fluoro-4-(6-(1-methyl-1H-tetrazol-5-yl)pyridin-3-yl)phenyl)-oxazolidin-2-one-5-yl]methyl, Het1, Het2, C(═O)C1-4alkyl, (CH2)mC(═O)C1-4alkyl, (CH2)m C3-6cycloalkyl, (CH2)mC(═O)-aryl, and(CH2)mC(═O)-Het1; R3 is selected from C1-20alkyl, C3-6cycloalkyl, C2-4alkenyl, C1-20heteroalkyl, aryl, heteroaryl, [3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2 H)-yl)phenyl)oxazolidin-2-one-5-yl]methyl, [3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one-5-yl]methyl, [3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-oxazolidin-2-one-5-yl ]methyl, [3-(3-fluoro-4-(6-(1-methyl-1H-tetrazol-5-yl)pyridine-3-yl) phenyl)-oxazolidin-2-one-5-yl]methyl, Het1, Het2, C(═O)C1-4alkyl, (CH2)mC(═O)C1-4alkyl, (CH2)mC3-6cycloalkyl, (CH2)mC(═O)-aryl, and (CH2)mC(═O)-Het1; wherein the C1-20 alkyl in R3 is optionally substituted with one, two, or three substituents selected from the group consisting of aryl, Het1, and Het2; each Het1 is independently a C-linked, five or six-membered, monocyclic or bicyclic heterocyclic ring which is aromatic, saturated, or unsaturated and comprises 1, 2, 3, or 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and S(O)n within the ring and where the remaining atoms are carbon; and where Het1 is optionally substituted with 1, 2, or 3 groups independently selected from oxo, aryl, halo, CN, —C1-4alkyl, —OH, —OC1-4alkyl, —S(O)nC1-4alkyl, —C1-4alkylNH2, —NHC1-4 alkyl, —C(═O)H, and —C═N—ORd; each Het2 is independently an N-linked, five or six-membered, monocyclic or bicyclic heterocyclic ring which is aromatic, saturated, or unsaturated and comprises 1, 2, 3, or 4 nitrogen atoms and optionally comprises one oxygen or sulfur atom, and where the remaining atoms are carbon; and where Het2 is optionally substituted with 1, 2, or 3 groups independently selected from oxo, aryl, halo, CN, —C1-4 alkyl, —OH, —OC1-4alkyl, —S(O)nC1-4alkyl, —C1-4alkylNH2—NHC1-4alkyl, —C(═O)H, and —C═N—ORd; n is 0, 1, or 2; and Rd is hydrogen or C1-4alkyl. |
