METHOD FOR MANUFACTURING 3-HYDROXYBUTYRIC ACID USING HALOMONAS SP.

摘要

The invention provides a process for producing 3-hydroxybutyric acid or a salt thereof, the process comprising culturing one or more halophilic bacteria belonging to the genus Halomonas under specific conditions.

主权项

1. A process for producing 3-hydroxybutyric acid or a salt thereof, the process comprising the following steps (1) to (3):
(1) step 1 of culturing one or more halophilic bacteria belonging to the genus Halomonas under aerobic conditions in a medium containing an organic carbon source and an inorganic salt; (2) step 2 of changing the culture conditions in step 1 from aerobic culture to microaerobic culture, and culturing bacterial cells of the halophilic bacteria to produce 3-hydroxybutyric acid or a salt thereof in a culture medium; and (3) step 3 of collecting the 3-hydroxybutyric acid or the salt thereof from the culture medium obtained in step 2.