发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE INTERACTIONS |
摘要 |
The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGFβ). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts. |
申请公布号 |
US2016264955(A1) |
申请公布日期 |
2016.09.15 |
申请号 |
US201615043789 |
申请日期 |
2016.02.15 |
申请人 |
ProteaPex Therapeutics, LLC |
发明人 |
D'Angelo Marina;Selim Abdulhafez A. |
分类号 |
C12N9/64 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
1. A synthetic compound with binding affinity for a hemopexin domain of a MMP protein or a matrix metalloprotease (MMP) substrate protein, wherein the compound is able to competitively inhibit binding the MMP to the substrate protein. |
地址 |
Philadelphia PA US |