| 发明名称 |
INHIBITION OF A lncRNA FOR TREATMENT OF MELANOMA |
| 摘要 |
This disclosure relates to the field of cancer, particularly the field of melanoma. It was found that a particular long non-coding RNA (lncRNA) is specifically up-regulated in melanoma (but not other tumor) cells as compared to melanocytes. Inhibition of this lncRNA in melanoma cells leads to induction of apoptosis and is a novel therapeutic strategy in the treatment of melanoma. |
| 申请公布号 |
US2016271163(A1) |
申请公布日期 |
2016.09.22 |
| 申请号 |
US201414913629 |
申请日期 |
2014.08.20 |
| 申请人 |
VIB VZW ;KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D ;UNIVERSITEIT GENT |
发明人 |
Marine Jean-Christophe;Leucci Eleonora;Vandesompele Joke;Mestdagh Pieter |
| 分类号 |
A61K31/713;C12Q1/68;C12N15/113;A61K45/06 |
主分类号 |
A61K31/713 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. An inhibitor of functional expression of LINC01212 which inhibitor is selected from the group consisting of a gapmer, a shRNA, a siRNA, a CRISPR, a TALEN, and a Zinc-finger nuclease. |
| 地址 |
Gent BE |
