发明名称 |
ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION AND ITCH |
摘要 |
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPV4 inhibitor. Further provided are compositions including a TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application. Further provided is a transgenic mouse whose genome includes deletions of the Trpv4 gene in keratinocytes of the epidermis, wherein said transgenic mouse is a knockout for the Trpv4 gene in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme. |
申请公布号 |
EP2869897(A4) |
申请公布日期 |
2016.09.28 |
申请号 |
EP20130813477 |
申请日期 |
2013.07.05 |
申请人 |
DUKE UNIVERSITY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LIEDTKE, WOLFGANG;STEINHOFF, MARTIN;GUILAK, FARSHID |
分类号 |
A61P17/00;A61K31/425;A61K31/4439;A61P29/00 |
主分类号 |
A61P17/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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