发明名称 |
Kappa opiatagonists for treating bladder diseases |
摘要 |
<p>Use of asimadoline (N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2,-diphenyl- acetamide) (I) or its salts, for treating diseases of the bladder. ACTIVITY : Uropathic; Analgesic. Bladder irritation was induced in rats by intraperitoneal injection of 100 ml/kg of physiological saline ( J. Pharmacol. Exp. Ther., 79 (1943) 97). The animals were treated with (I), the bladders were emptied by abdominal massage, then urine was collected over the next 6 hours. (I) Doubled the amount of urine excreted. MECHANISM OF ACTION : Kappa opiate receptor agonist.</p> |
申请公布号 |
EP1834640(A2) |
申请公布日期 |
2007.09.19 |
申请号 |
EP20070111669 |
申请日期 |
2002.03.13 |
申请人 |
TIOGA PHARMACEUTICALS, INC. |
发明人 |
JACOB, JUTTA;WEBER, FRANK;BARTOSZYK, GERD;SEYFRIED, CHRISTOPH |
分类号 |
A61K31/40;C07D207/12;A61K31/401;A61P7/10;A61P7/12;A61P13/10;A61P25/02 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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