Preparation of antigen-presenting human gamma delta T cells and use in immunotherapy

摘要

Provided is a method for the preparation of efficient antigen-presenting human gamma delta T cells comprising selecting gamma delta T cells out of human peripheral blood mononuclear cells, treating the selected cells with a stimulus for induction of antigen-presenting functions, and applying the antigen for uptake and presentation by these cells. Further provided are antigen presenting gamma delta T cell produced by the method, use of said T cells for the manufacture of a vaccine and related methods of identifying novel antigens and diagnosis patient immunocompetence.