COMPOSITIONS AND METHODS FOR TREATING CXCR6/CXCL16 ASSOCIATED DISEASES

摘要

Soluble molecules are provided. Thus, for example, provided is a soluble polypeptide comprising a heterologous amino acid sequence conjugated to a CXCR6 amino acid sequence comprising an N-terminus domain of CXCR6, the CXCR6 amino acid sequence being capable of binding CXCL16, and wherein the molecule is non-immunogenic in a human subject. Use of such molecules in the treatment of inflammatory diseases in general and Multiple Sclerosis in particular is also envisaged.