AFFINITY CHROMATOGRAPHY MATRIX

摘要

The invention relates to an affinity chromatography matrix, as a gel, comprising polymeric particles on which at least one oligosaccharide corresponding to a blood group A epitope and/or blood group B is grafted, via a spacer, characterized in that the density of oligosaccharides is comprised between 0.2 and 0.7 mg/ml of matrix. The invention also relates to the uses of this matrix for preparing concentrates of immunoglobulins for therapeutic use.

主权项

1. An affinity chromatography matrix, in form of a gel, comprising polymeric particles on which at least one oligosaccharide corresponding to a blood group A and/or group B epitope is grafted, said oligosaccharide being grafted to said particles via a spacer, wherein the density of oligosaccharides is comprised between 0.2 and 0.7 mg/ml of matrix and said spacer has a formula (I) —NH—R1-CO—NH—R2-, wherein R1 is a C4-C6 alkyl group, R2 is a C3-C8 alkyl group, and said spacer is bound through its amine function to the particle.