Cyclic peptides as ADAM protease inhibitors

摘要

The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.

主权项

1. A cyclic peptide of formula I: wherein X0, X1, X2 and X3 each independently represents an amino acid residue; wherein each amino acid residue in the cyclic peptide is joined by a peptide bond; wherein each X0 may be the same or different; wherein X1, X2 and X3 are selected such that the cyclic peptide comprises one of the following amino acid sequences: KDM, TSE, ARQ, DSD, NAT, VRQ, and TDD; and wherein n is 0 to 4; or a pharmaceutically acceptable salt thereof.