| 发明名称 |
INHIBITORS OF HUMAN 12/15-LIPOXYGENASE |
| 摘要 |
A systematic screening has revealed a family of compounds that exhibit inhibitory effects on 12/15-lipoxygenase. Accordingly, the present invention relates to the use of these compounds for the inhibition of 12/15-lipoxygenase and for the treatment of a condition involving 12/15-lipoxygenase. Exemplary conditions include, but are not limited to, stroke, periventricular leukomalacia, cardiac arrest with resuscitation, atherosclerosis, Parkinson's disease, Alzheimer's disease, and breast cancer. |
| 申请公布号 |
US2016168137(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201615048330 |
申请日期 |
2016.02.19 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION ;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANTA CRUZ ;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV |
发明人 |
VAN LEYEN Klaus;HOLMAN Theodore R.;MALONEY David J.;JADHAV Ajit;SIMEONOV Anton;RAI Ganesha |
| 分类号 |
C07D413/04;C07D277/56;C07D263/48 |
主分类号 |
C07D413/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a condition involving 12/15-lipoxygenase in a subject, the method comprising administering to the subject an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is O or S; R11 is an aryl, heteroaryl, cyclyl, or heterocyclyl, each of which can be optionally substituted; and R12 and R13 are independently hydrogen, halogen, alkyl, alkenyl, alkynyl, aralkyl, acyl, aryl, heteroaryl, cyclyl or heterocyclyl, each of which can be optionally substituted. |
| 地址 |
Boston MA US |
