主权项 |
1. A compound according to Formula I wherein R1 is H, —CH3, —CF3, or cyclopropyl; L is —NR4—; the subscript m is 0, or 1; R2 is
C1-4 alkyl or C1-4 alkyl substituted with one or more independently selected R5 groups,C3-7 cycloalkyl,4-10 membered monocyclic, bridged-, spiro-, or fused bicyclic heterocycloalkyl comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected Ra groups,5-6 membered monocyclic heterocycloalkenyl comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected Ra groups,C6-10 mono or bicyclic aryl optionally substituted with one or more independently selected Rb, or5-10 membered monocyclic or fused bicyclic heteroaryl, comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected Rb; R3 is
C3-7 cycloalkyl optionally substituted with one or more independently selected Rc groups,4-7 membered monocyclic heterocycloalkyl comprising one or more heteroatoms independently selected from O, and S, and optionally substituted with Rc,C6-10 mono or bicyclic aryl optionally substituted with one or more independently selected Rd groups,phenyl fused to a 5-6 membered heterocycloalkyl comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected Rd groups,phenyl fused to a C5-6 cycloalkyl, optionally substituted with one or more independently selected Rd groups,5-10 membered mono or fused bicyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected Rd groups,5-6 membered monocyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, and S, fused to a 5-6 membered heterocycloalkyl comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected Rd groups,5-6 membered monocyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, and S, fused to a C5-6 cycloalkyl comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected Rd groups,C2-6 alkenyl,C3-6 alkyl, orC1-6 alkyl substituted with one or more independently selected Re groups; R4 is
C1-6 alkyl or C1-6 alkyl substituted with one or more independently selected R6 groups, orC3-7 cycloalkyl; each R5 is independently selected from
halo,OH,—CN,C1-4 alkoxy,—NR8eR8f,C3-7 cycloalkyl,6 membered mono or fused bicyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, and S, andphenyl optionally substituted with one or more independently selected
halo,C1-4 alkyl optionally substituted with one or more independently selected halo, orC1-4 alkoxy; each R6, is independently selected from
halo,OH,—CN,—NR8gR8h, andC1-4 alkoxy; each Ra is selected from
halo,CN,oxo,C1-4 alkyl or C1-4 alkyl substituted with one or more independently selected R7a,C1-4 alkoxy or C14 alkoxy substituted with one or more independently selected R7a,—C(═O)O—C1-4 alkyl,phenyl,5-10 membered mono, or fused bicyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, or S, and optionally substituted with one or more independently selected C1-4 alkyl, and—NR8aR8b; each Rb is selected from
halo,—CN,C1-4 alkyl or C1-4 alkyl substituted with one or more independently selected R7b,C1-4 alkoxy or C1-4 alkoxy substituted with one or more independently selected R7b,—OC(═O)C1-4 alkyl, and—NR8cR8d; each Rc is selected from
halo,OH,—CN,oxo,C1-4 alkyl or C1-4 alkyl substituted with one or more independently selected R7c),C1-4 alkoxy or C1-4 alkoxy substituted with one or more independently selected R7c),phenyl or phenyl substituted with one or more independently selected halo, C1-4 alkyl,C1-4 alkoxy, —CN, or —NR9aR9b), and5-6 membered monocyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, or S or N, O, or S substituted with one or more independently selected halo, C1-4 alkyl, C1-4 alkoxy, CN, —NR9cR9d; each Rd is selected from
halo,—CN,—OH,C1-4 alkyl or C1-4 alkyl substituted with one or more independently selected R7d,C1-4 alkoxy or C1-4 alkoxy substituted with one or more independently selected R7d,C3-7 cycloalkyl,5-10 membered mono or fused bicyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, or S, and—NH-Phenyl; each Re is selected from
halo,OH,—CN,C1-4 alkoxy or C1-4 alkoxy substituted with one or more independently selected R7e,C3-7 cycloalkyl,phenyl or phenyl with one or more independently selected halo, C1-4 alkyl, C1-4 alkoxy, CN, and —NR9eR9f, and5-6 membered monocyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, and S or N, O, and S substituted with one or more independently selected halo, C1-4 alkyl, C1-4 alkoxy, CN, and —NR9gR9h; each R7a, R7b, R7c, R7d, and R7e is independently selected from
halo,OH,—CN,—NR8iR8j, andC1-4 alkoxy; each R8a, R8b, R8c, R8d, R8e, R8f, R8g, R8h, R8i, or R8j is independently selected from H, and C1-4 alkyl; each R9a, R9b, R9c, R9d, R9e, R9f, R9g, or R9h is independently selected from H, and C1-4 alkyl; or a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof. |