| 主权项 |
1. A compound of formula (I): in which: R1 represents a phenyl- or a pyridyl- group;
which is substituted, one or more times, identically or differently, with a substituent selected from: R6—(C1-C6-alkoxy)-, R6—O—, —C(═O)R6, —C(═O)O—R6, —N(H)C(═O)R6, —N(H)C(═O)NR6R7, —NR6R7, —C(═O)N(H)R6, —C(═O)NR6R7, R6—S—, R6—S(═O)2—, —N(H)S(═O)2R6, and —S(═O)2N(H)R6; andwhich is optionally substituted, one or more times, identically or differently, with a substituent selected from: halo-, hydroxy-, nitro-, C1-C6-alkyl-, C1-C6-alkoxy-, hydroxy-C1-C6-alkyl-, —N(H)C(═O)R8, —N(H)C(═O)NR8R7, —C(═O)N(H)R8, and —N(H)S(═O)2R8; R2 represents: wherein * indicates the point of attachment of said group with the rest of the molecule; A represents a 4- to 6-membered heterocyclic ring; which is optionally substituted, one or more times, identically or differently, with halo-, —CN, —OH, nitro-, C1-C6-alkyl-, halo-C1-C6-alkyl-, C1-C6-alkoxy-, halo-C1-C6-alkoxy-, hydroxy-C1-C6-alkyl-, R8—(C1-C6-alkoxy)-, R8—O—, —NR8R7, R8—S—, R8—S(═O)—, R8—S(═O)2—, or (C3-C6-cycloalkyl)-(CH2)n—O—; B represents a 4- to 6-membered heterocyclic ring; which is optionally substituted, one or more times, identically or differently, with halo-, —CN, —OH, nitro-, C1-C6-alkyl-, halo-C1-C6-alkyl-, C1-C6-alkoxy-, halo-C1-C6-alkoxy-, hydroxy-C1-C6-alkyl-, R8—(C1-C6-alkoxy)-, R8—O—, —NR8R7, R8—S—, R8—S(═O)—, R8—S(═O)2—, or (C3-C6-cycloalkyl)-(CH2)n—O—; R3 represents a hydrogen atom; R4 represents a hydrogen atom; R5 represents a hydrogen atom or a C1-C3-alkyl- group; each R5a independently represents a group selected from:
halo-, nitro-, C1-C6-alkyl-, halo-C1-C6-alkyl-, C1-C6-alkoxy-, hydroxy-C1-C6-alkyl-, R8—(C1-C6-alkoxy)-, R8—O—, —NR8R7, R8—S—, R8—S(═O)—, R8—S(═O)2—, and (C3-C6-cycloalkyl)-(CH2)n—O—; R6 represents a group selected from:
C3-C6-cycloalkyl-, 3- to 10-membered heterocycloalkyl-,aryl-, heteroaryl-, —(CH2)q—(C3-C6-cycloalkyl), —(CH2)q-(3- to 10-membered heterocycloalkyl), —(CH2)q-aryl and —(CH2)q-heteroaryl;wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from:halo-, hydroxy-, cyano-, nitro-, C1-C6-alkyl-, halo C1-C6 alkyl, hydroxy-C1-C6-alkyl-, —C6-alkoxy-C1-C6-alkyl-, —C6-alkoxy-C1-C6-alkyl-, R8—(CH2)n(CHOH)(CH2)m—, R8—(C1-C6-alkoxy)-, R8—(CH2)n(CHOH)(CH2)p—O—, R8—(C1-C6-alkoxy-C1-C6-alkyl)-O—, aryl-, R8—O—, —C(═O)R8, —C(═O)O—R8, —OC(═O)—R8, —N(H)C(═O)R8, —N(R7)C(═O)R8, —N(H)C(═O)NR8R7, —N(R7)C(═O)NR8R7, —N(H)R8, —NR8R7, —C(═O)N(H)R8, —C(═O)NR8R7, R8—S(═O)—, R8—S(═O)2—, —N(H)S(═O)R8, —N(R7)S(═O)R8, —S(═O)N(H)R8, —S(═O)NR8R7, —N(H)S(═O)2R8, —N(R7)S(═O)2R8, —S(═O)2N(H)R8, —S(═O)2NR8R7, —S(═O)(═NR8)R7, —S(═O)(═NR7)R8, and —N═S(═O)(R8)R7; R7 represents a C1-C3-alkyl- or a C3-C6-cycloalkyl- group; R8 represents a hydrogen atom or a C1-C6-alkyl- or C3-C6-cycloalkyl- group; wherein said C1-C6-alkyl- or C3-C6-cycloalkyl- group is optionally substituted, one or more times, identically or differently, with a substituent selected from:
halo-, hydroxy-, —NHR7, —NR7R7, —N(C1-C3-alkyl)-C(═O)R7, —N(C1-C3-alkyl)-C(═O)OR7, R7—S(═O)2—, C1-C3-alkoxy-, and halo —C3-alkoxy-; or R7 and R8 together with the molecular fragment they are attached to represent a 4- to 6-membered heterocycloalkyl- group, which is optionally substituted, one or more times, identically or differently, with a halogen atom, a C1-C3-alkyl-, halo-C1-C3-alkyl- or C1-C3-alkoxy- group; n, m, and p,
represent, independently from each other, an integer of 0, 1, 2 or 3; q represents an integer of 0, 1, 2 or 3; and t represents an integer of 0, 1 or 2;or a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. |
