发明名称 |
A PROCESS FOR PREPARATION OF DEXMETHYLPHENIDATE HYDROCHLORIDE |
摘要 |
The present invention relates to a process for preparation of dexmethylphenidate hydrochloride from racemic methylphenidate. The process involves the treatment of racemic mixture of dl-throe-methylphenidate base in the presence of di-pivaloyl-D-tartaric acid (D-DPTA) in a solvent to isolate dipivaloyl tartrate salt of d-threo-methylphenidate. The dipivaloyl tartrate salt of d-threo-methylphenidate is treated with a base to obtain a d-threo-methylphenidate base, which is extracted using a suitable solvent. The d-threo-methylphenidate base is treated with hydrochloric acid-isopropyl alcohol solution to obtain slurry of d-threo-methylphenidate hydrochloride also known as dexmethylphenidate hydrochloride. The dexmethylphenidate hydrochloride slurry is filtered and washed with acetone. The invention also discloses a process for recovery of D-DPTA from the salt mother liquor and from the spent aqueous layer. The process is economical, environmental friendly and results in increased yield and optically pure dexmethylphenidate hydrochloride. |
申请公布号 |
WO2016157065(A2) |
申请公布日期 |
2016.10.06 |
申请号 |
WO2016IB51745 |
申请日期 |
2016.03.28 |
申请人 |
EMBIO LIMITED |
发明人 |
GUPTE, Ashutosh Digambar;JOSHI, Sunil Vaman;PAKHURDE, Amit Hari |
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