| 摘要 |
FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to a method for carbamoylation reaction of alcohol having both alcoholic moiety and basic moiety and/or sulfenyl moiety. Method involves mixing cyanate with indicated alcohol in inert solvent in anhydrous conditions, cooling formed reaction mixture to temperature from about -25°C to about 40°C, addition of acid to the cooled reaction mixture at the rate maintaining temperature lower 0°C, stirring the acid-containing reaction mixture at temperature from about -10°C to about 0°C for about 8-10 h and treatment of the reaction mixture with water. Method can be used for carbamoylation reaction of capravirine sulfenyl alcohol. Method provides enhancing conversion of alcohol and yield of carbamate. ^ EFFECT: improved method for carbamoylation reaction. ^ 11 cl, 3 ex |
