| 发明名称 | Method for improving the production of influenza viruses and vaccine seeds | ||
| 摘要 | The present invention relates to a method for improving the production of an influenza virus, and in particular influenza vaccine seeds, or a vaccine directed against an influenza virus, characterized in that the production is carried out in the presence of an inhibitor of the interaction between the Mdm2 protein and the p53 protein. | ||
| 申请公布号 | US9381238(B2) | 申请公布日期 | 2016.07.05 |
| 申请号 | US201113883310 | 申请日期 | 2011.11.04 |
| 申请人 | UNIVERSITY OF DUNDEE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE CLAUDE BERNARD LYON I;HOSPICES CIVILS DE LYON | 发明人 | Terrier Olivier;Bourdon Jean-Christophe;Rosa-Calatrava Manuel |
| 分类号 | A61K39/145;C12N7/00;A61K39/12 | 主分类号 | A61K39/145 |
| 代理机构 | Clark & Brody | 代理人 | Clark & Brody |
| 主权项 | 1. A method for producing an influenza virus comprising: a) infecting a cell system that excludes human beings with an influenza virus; b) adding an Mdm2 antagonist to the cell system before, after, or at the same time as said infecting, c) incubating in the presence of the Mdm2 antagonist the cell system selected and infected in step a) under conditions which allow replication of said influenza virus; and d) harvesting of the whole influenza virus produced. | ||
| 地址 | Dundee GB | ||