发明名称 |
Interferon analogs |
摘要 |
The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor. |
申请公布号 |
US9381230(B2) |
申请公布日期 |
2016.07.05 |
申请号 |
US201013519808 |
申请日期 |
2010.12.30 |
申请人 |
BiOrion Technologies, B.V. |
发明人 |
Poelstra Klaas;Prakash Jai;Beljaars Eleonora;Bansal Ruchi |
分类号 |
A61K38/21;C07K14/555;C07K14/57;A61K38/12;C07K5/083;C07K5/09;C07K5/093 |
主分类号 |
A61K38/21 |
代理机构 |
Sunstein Kann Murphy & Timbers LLP |
代理人 |
Sunstein Kann Murphy & Timbers LLP |
主权项 |
1. An analog of interferon gamma (IFNγ) the analog comprising the amino acid sequence set forth in SEQ ID NO: 56 or the amino acid sequence set forth in SEQ ID NO: 58. |
地址 |
Groningen NL |