发明名称 |
Synthesis of aryl ethers |
摘要 |
A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. The aromatic compound comprises an activated substituent, X, said activated substituent being a moiety such that its conjugate acid HX has a pKa of less than 5.0. The catalyst is preferably a soluble palladium complex in the presence of supporting ligands. |
申请公布号 |
US6166226(A) |
申请公布日期 |
2000.12.26 |
申请号 |
US19980206820 |
申请日期 |
1998.12.08 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
BUCHWALD, STEPHEN L.;WOLFE, JOHN P.;PALUCKI, MICHAEL |
分类号 |
B01J31/22;B01J31/24;C07B61/00;C07C41/16;C07C43/20;C07C43/225;C07C43/235;C07C253/30;C07C255/54;C07D307/79;C07D309/12;C07D311/46;C07D311/58;C07D311/80;C07D311/82;C07D311/94;C07D313/08;(IPC1-7):C07D313/00;C07D319/06;C07D311/92;C07D255/00;C07D43/20 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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