发明名称 |
Crystal structure of a deacetylase and inhibitors thereof |
摘要 |
The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.
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申请公布号 |
US2007100559(A1) |
申请公布日期 |
2007.05.03 |
申请号 |
US20060505196 |
申请日期 |
2006.08.16 |
申请人 |
PAVLETICH NIKOLA;FINNIN MICHAEL;DONIGIAN JILL;RICHON VICTORIA M;RIFKIND RICHARD A;MARKS PAUL A;BRESLOW RONALD |
发明人 |
PAVLETICH NIKOLA;FINNIN MICHAEL;DONIGIAN JILL;RICHON VICTORIA M.;RIFKIND RICHARD A.;MARKS PAUL A.;BRESLOW RONALD |
分类号 |
G01N33/50;G06F19/00;C12N9/16;C12N9/18;C12N9/80;C12N15/09;C12Q1/34;G01N33/15;G01N33/566;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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