Nifedipine controlled release compositions and preparation methods therefor

摘要

A nifedipine controlled release composition is provided comprising a drug-layer and a push-layer at a ratio of 1:0.5~3 by weight. The drug-layer contains nifedipine and 40~99 percent by weight of the drug-layer of hydrophilic polyvinylpyrrolidone homopolymer and/or copolymer carrier. The push-layer comprises about 10 to 80 percent by weight of the push-layer of osmopolymers, about 10 to 80 percent by weight of the push-layer of water-insoluble polymers, and about 5 to 50 percent by weight of the push-layer of osmagents. The composition is used in osmotic pump tablets for controlled release of nifedipine useful for administration once a day.