BIOMARKER FOR DIAGNOSIS OF LIVER DISEASE

摘要

Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed against the marker; a diagnostic agent; a diagnosis method; and a method for detecting a blood or serum. The full-length sequence of kininogen and three partial peptides thereof (sequence A; position-440 to position-456, sequence B; position-439 to position-456, and sequence C; position-438 to position-456), whose quantities in a serum collected from a patient suffering from non-alcoholic fatty liver disease are significantly different from those in a serum collected from a normal person, are found by the analysis on proteomes, and a detection method that can be utilized conveniently in a diagnostic agent or a medical examination of non-alcoholic fatty liver disease can be established. The use of a combination of a kininogen-type marker and a C4-type marker (the full-length sequence or a partial peptide thereof) enables the identification of non-alcoholic fatty liver disease, chronic hepatitis and an asymptomatic virus carrier.