| 发明名称 |
RAPID-ACTING INSULIN COMPOSITIONS |
| 摘要 |
The invention is a composition of human insulin or insulin analog that includes specific concentrations of citrate, chloride, in some cases including the addition of sodium chloride, zinc and, optionally, magnesium chloride and/or surfactant, and that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products. |
| 申请公布号 |
US2016166695(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201514963279 |
申请日期 |
2015.12.09 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
AKERS MICHAEL PATRICK;NGUYEN CHI A.;PAAVOLA CHAD D.;SARIN VIRENDER KUMAR;SCHULTE NANETTE ELIZABETH;MAJUMDAR RANAJOY |
| 分类号 |
A61K47/12;A61K47/02;A61K38/28 |
主分类号 |
A61K47/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising:
a. an insulin; b. citrate, in a concentration from about 10 to about 30 mM; c. zinc, in a concentration from about 0.2 to about 2 mM; d. magnesium, in a concentration from about 1 to about 15 mM; e. total chloride, in a concentration from about 10 to about 60 mM; f. a surfactant, in a concentration from about 0.001 to about 0.2% w/v; and g. a preservative. |
| 地址 |
INDIANAPOLIS IN US |
