COMBINATION THERAPY USING A FACTOR XII INHIBITOR AND A C-1 INHIBITOR

摘要

Methods and compositions are disclosed for treating disorders of the contact activation system, comprising the administration of at least one C1-Inhibitor (C1-INH) and at least one Factor XII (FXII) inhibitor.

主权项

1. A composition comprising an effective amount of at least one Factor XII (FXII) inhibitor and at least one C1-Inhibitor (C1-INH) for the use of treating a disorder of the contact activation system selected from a thrombotic disorder, an interstitial lung disorder, a fibroproliferative disorder, idiopathic pulmonary fibrosis, a neurological inflammatory disorder, a disorder related to kinin formation, a disorder of the complement activation system, and an ischemia-reperfusion injury (IRI) wherein the FXII inhibitor is not C1 INH.