| 发明名称 |
TREATMENT OF METABOLIC DISEASES BY INHIBTION OF HTR2A OR HTR3 |
| 摘要 |
The present invention relates to a method for preventing or treating a metabolic disease, which comprises inhibiting HTR2A (5-hydroxytryptamine 2A receptor) or HTR3A (5-hydroxytryptamine 3A receptor). The inhibition of HTR3A leads to various advantageous efficacies for therapy of metabolic diseases, including resistance to obesity, decrease of lipid droplet size, increase of expression levels of thermogenic genes, increase of metabolic activities, increase of insulin sensitivity and decrease of LDL cholesterol and leptin. |
| 申请公布号 |
US2016228452(A1) |
申请公布日期 |
2016.08.11 |
| 申请号 |
US201514611143 |
申请日期 |
2015.01.30 |
| 申请人 |
Korea Advanced Institute of Science and Technology |
发明人 |
KIM Ha Il;PARK Sang Kyu |
| 分类号 |
A61K31/554;A61K31/519;A61K31/496;A61K31/551;A61K31/407;A61K31/445;A61K31/4178;A61K31/46;A61K31/439;A61K31/473;A61K31/4184;A61K31/437;A61K31/166;A61K45/06;G01N33/50;C12Q1/68;A61K31/517 |
主分类号 |
A61K31/554 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for preventing or treating a metabolic disease, which comprises inhibiting HTR2A (5-hydroxytryptamine 2A receptor) or HTR3 (5-hydroxytryptamine 3 receptor) in a subject in need thereof. |
| 地址 |
Daejeon KR |
