发明名称 |
Pharmaceutical Formulation |
摘要 |
A pharmaceutical composition in the form of a tablet including a first portion and a second portion, wherein the first portion includes guaifenesin having an immediate release profile and a second drug having a sustained release profile, and wherein the second portion includes guaifenesin having a sustained release profile. The second drug can be in the form of a drug-resin complex. The second drug can be either an anti-tussive or a decongestant. The drug-resin complex includes a drug complexed to an ion exchange resin. The ion exchange resin can be a polystyrene sulfonate resin, polacrilex resin, polacrilin potassium, cholestyramine resin, or a colestyramine resin. The drug-resin complex can be provided with a coating, the coating thickness being selected to obtain the desired release profile. The drug-resin complex can be provided with a coating level of from 5% to 50%. The coating level can be from 10% to 35%. |
申请公布号 |
US2016228386(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
US201615133062 |
申请日期 |
2016.04.19 |
申请人 |
Reckitt Benckiser LLC |
发明人 |
Ahlgren Nils;Nuttall Mark;Wong Jeannie;Balasubramanian Venkatesh;Belongie Craig;Khan Ashfaq;Muir Neil Campbell |
分类号 |
A61K31/09;A61K9/20;A61K9/48;A61K9/50;A61K31/485;A61K9/24 |
主分类号 |
A61K31/09 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical composition comprising:
a first portion; and a second portion; wherein the first portion comprises guaifenesin having an immediate release profile and a second drug having a sustained release profile; and wherein the second portion comprises guaifenesin having a sustained release profile. |
地址 |
Parsippany NJ US |