发明名称 |
Anti-TNF-alpha glycoantibodies and uses thereof |
摘要 |
The present disclosure relates to a novel class of anti-TNFα monoclonal antibodies or antigen binding fragments comprising a homogeneous population of anti-TNFα IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-TNFα monoclonal antibodies by Fc glycoengineering. The glycoantibodies of the invention may have improved therapeutic values compared to the corresponding monoclonal antibodies that have not been glycoengineered. |
申请公布号 |
AU2015267044(A1) |
申请公布日期 |
2016.12.15 |
申请号 |
AU20150267044 |
申请日期 |
2015.05.27 |
申请人 |
Academia Sinica |
发明人 |
Wong, Chi-Heuy;Wu, Chung-Yi |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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