CHIMERIC OLIGOMERIC COMPOUNDS COMPRISING ALTERNATING REGIONS OF NORTHERN AND SOUTHERN CONFORMATIONAL GEOMETRY
摘要
The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3'-endo conformational geometry (3'-endo regions) or DNA like having southern or C2'-endo/O4'-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.
申请公布号
WO2005023995(A3)
申请公布日期
2007.09.20
申请号
WO2004US29821
申请日期
2004.09.09
申请人
ISIS PHARMACEUTICALS, INC.;MONIA, BRETT, P.;BUTLER, MADELINE, M.;MCKAY, ROBERT;BAKER, BRENDA, F.
发明人
MONIA, BRETT, P.;BUTLER, MADELINE, M.;MCKAY, ROBERT;BAKER, BRENDA, F.