| 摘要 |
<p>Lambda combined rapid ueting-long acting insulin formulation has been developed wherein the pll of the rapid acting insulin is adjusted so that the long acting giargine remains soluble when they are mixed together, tn the preferred embodiment, this injectable basal bolus insulin, is administered before breakfast, prm ides adequate bolus insulin levels to cover the meal, does not produce hypogly cemia alter tbc meal and provides, adequate basal insulin for 24 hours. Lunch and dinner can be covered by two bolus injections of a fast acting, or a rapid acting or a v ery rapid acting insulin. As a result, a patieni using intensive insulin iherap) should only inject three, rather than four, times a day. Fxperiments have been performed to demonstrate the importance of the addition of specific acids to hexameric insulin to enhance speed and amount of absorption and preserve bioactivity follow ing dissociation into the mopiomerie form by addition of a chelator such as KDTLambda.</p> |
