| 发明名称 |
Acceptor framework for CDR grafting |
| 摘要 |
The present invention relates to an antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a particularly well suited antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications. |
| 申请公布号 |
US9403903(B2) |
申请公布日期 |
2016.08.02 |
| 申请号 |
US201514706484 |
申请日期 |
2015.05.07 |
| 申请人 |
ESBATECH, AN ALCON BIOMEDICAL RESEARCH UNIT LLC |
发明人 |
Escher Dominik |
| 分类号 |
C07H21/00;C07K16/18;C07K16/46 |
主分类号 |
C07H21/00 |
| 代理机构 |
|
代理人 |
Derry Jason J. |
| 主权项 |
1. An isolated nucleic acid encoding a human heavy chain acceptor framework comprising SEQ ID NO: 1, wherein the human heavy chain acceptor framework comprises an amino acid substitution at position 12, 103, and/or 144 (Aho numbering). |
| 地址 |
Fort Worth TX US |
