发明名称 |
METHOD FOR FULLY AUTOMATED SYNTHESIS OF 16β-18F-FLUORO-5α-DIHYDROTESTOSTERONE (18F-FDHT) |
摘要 |
The automated synthesis of clinically relevant amounts of 16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes with a decay-corrected radiochemical yield of 29±5%. The specific activity was 4.6 Ci/µmol (170 GBq/µmol) at end of formulation with a starting activity of 1.0 Ci (37 GBq). The formulated 18F-FDHT yielded sufficient activity for multiple patient doses and passed all quality control tests required for routine clinical use. |
申请公布号 |
WO2016126875(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
WO2016US16450 |
申请日期 |
2016.02.03 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MURPHY, JENNIFER MARIE;LAZARI, MARK SAUL |
分类号 |
C07J1/00;C07J75/00 |
主分类号 |
C07J1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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