| 发明名称 | Antibodies to human B7x for treatment of metastatic cancer | ||
| 摘要 | Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis. | ||
| 申请公布号 | US9447186(B2) | 申请公布日期 | 2016.09.20 |
| 申请号 | US201314050512 | 申请日期 | 2013.10.10 |
| 申请人 | Albert Einstein College of Medicine, Inc.;Sloan-Kettering Institute for Cancer Research | 发明人 | Zang Xingxing;Allison James P. |
| 分类号 | C07K16/28;A61K39/395;G01N33/50;A61K45/06;C07K16/30;A61K39/00 | 主分类号 | C07K16/28 |
| 代理机构 | Amster, Rothstein & Ebenstein LLP | 代理人 | Amster, Rothstein & Ebenstein LLP |
| 主权项 | 1. A method for treating metastatic cancer in a patient having metastatic cancer or for preventing metastasis in a cancer patient at risk for metastasis comprising administering to the patient an IgG1 monoclonal antibody, or a fragment thereof, that binds to B7x and decreases the number of tumor nodules in a patient, in an amount effective to decrease the number of tumor nodules and treat or prevent metastasis in a patient, wherein the antibody or antibody fragment binds to amino acid residues 35-148 of SEQ ID NO:1, and wherein the antibody or antibody fragment blocks inhibition of T cell function by B7x. | ||
| 地址 | Bronx NY US | ||