| 发明名称 |
LIVER X RECEPTOR AGONISTS IN THE TREATMENT OF EMPHYSEMA |
| 摘要 |
The present invention provides methods and compositions for treating a subject afflicted with chronic obstructive pulmonary disease (COPD) which comprise a i) a Liver X receptor (LXR) agonist, ii) a miR-33 antagonist, or iii) a TLR4/Myd88 pathway antagonist. The present invention also provides methods and compositions for use in prophylactically treating a subject for chronic obstructive pulmonary disease (COPD) which comprise i) a Liver X receptor (LXR) agonist, ii) a miR-33 antagonist, or iii) a TLR4/Myd88 pathway antagonist. |
| 申请公布号 |
US2016310454(A1) |
申请公布日期 |
2016.10.27 |
| 申请号 |
US201415105532 |
申请日期 |
2014.12.17 |
| 申请人 |
D'ARMIENTO Jeanine;SKLEPKIEWICZ Piotr;LEMAITRE Vincent |
发明人 |
D'Armiento Jeanine;Lemaitre Vincent |
| 分类号 |
A61K31/18;G01N33/92;A61K31/195;C12N15/113 |
主分类号 |
A61K31/18 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A method for treating a subject afflicted with chronic obstructive pulmonary disease (COPD) which comprises administering to the subject i) a Liver X receptor (LXR) agonist, ii) a miR-33 antagonist, or iii) a TLR4/Myd88 pathway antagonist in an amount that is effective to treat the subject. |
| 地址 |
New York NY US |
