发明名称 |
NANOPARTICLE COMPOSITIONS AND METHODS THEREOF TO RESTORE VASCULAR INTEGRITY |
摘要 |
The present invention relates to methods for treating systemic inflammation. In certain embodiments, the method comprises administering a therapeutically effective amount of curcumin-selenium loaded nanoparticles. The curcumin-selenium loaded nanoparticles can comprise a matrix of chitosan, polyethylene glycol and tetramethoxysilane encapsulating curcumin and selenium. In certain embodiments, the method comprises administering a therapeutically effective amount of nitric oxide-releasing nanoparticles. The nitric oxide-releasing nanoparticles can comprise a matrix of chitosan encapsulating nitric oxide. In certain embodiments, the systemic inflammation can be caused by endotoxemia. In certain embodiments, the systemic inflammation can be caused by a Filovirus, including an Ebola virus or a Marburg virus. In certain embodiments, the methods for treating systemic inflammation in a subject result in the reduction of proinflammatory cytokines in a subject. In certain embodiments, the method of treatment is a combination therapy. The present invention also relates to methods of making compositions comprising nanoparticles. |
申请公布号 |
WO2016094189(A1) |
申请公布日期 |
2016.06.16 |
申请号 |
WO2015US63751 |
申请日期 |
2015.12.03 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.;UNIVERSITY OF CALIFORNIA SAN DIEGO |
发明人 |
FRIEDMAN, JOEL, M.;NAVATI, MAHANTESH, S.;FRIEDMAN, ADAM, J.;CABRALES, PEDRO |
分类号 |
B82Y5/00;A61K31/05;A61K33/04 |
主分类号 |
B82Y5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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