摘要 |
<p>The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.</p> |
申请人 |
ABBOTT GMBH & CO. KG;LIU;ROSENBERG, JOERG;WOEHRLE, GERD;KESSLER, THOMAS Y.;BREITENBACH, JOERG;DURAK, SALIH;RICHTER, FRIEDRICH W.;DUTTA, SANDEEP |
发明人 |
ROSENBERG, JOERG;WOEHRLE, GERD;KESSLER, THOMAS Y.;BREITENBACH, JOERG;DURAK, SALIH;RICHTER, FRIEDRICH W.;DUTTA, SANDEEP |