| 发明名称 | Cancer-related glycopeptide epitopes, antibodies and methods of use | ||
| 摘要 | Cancer-associated O-glycopeptide combination epitopes derived from the VNTR of MUC1 are disclosed. Autoantibodies present in human sera target the combination epitopes and are reduced or absent in cancer patients. The epitopes are useful as therapeutic and immunoprophylactic cancer vaccines. Monoclonal antibodies directed against the epitopes are also useful as immunotherapeutics for treatment and prevention of cancer. Diagnostic methods using the epitopes and antibodies are also disclosed. | ||
| 申请公布号 | US9346867(B2) | 申请公布日期 | 2016.05.24 |
| 申请号 | US201113641610 | 申请日期 | 2011.04.15 |
| 申请人 | Sumitomo Bakelite Co., Ltd. | 发明人 | Nishimura Shin-Ichiro;Matsushita Takahiko;Miura Yoshiaki |
| 分类号 | C07K14/47;C07K16/30;A61P35/00;A61K38/16;A61K38/17 | 主分类号 | C07K14/47 |
| 代理机构 | Servilla Whitney LLC | 代理人 | Servilla Whitney LLC |
| 主权项 | 1. A synthetic glycopeptide which consists of SEQ ID NO:3, wherein glycosylation consists of 23ST at T15 of SEQ ID NO:3, or which consists of SEQ ID NO:4, wherein glycosylation consists of 23ST at T15 of SEQ ID NO:4. | ||
| 地址 | Tokyo JP | ||