Canine babesiosis vaccine antigen

摘要

The present invention relates to the field of veterinary parasitology, especially of canine Babesiosis. In particular the invention relates to a polypeptide being a novel canine Babesia antigen (CBA), or fragments thereof, and to compositions comprising this antigen, to nucleic acids encoding the antigen, antibodies against the antigen, and medical uses of this antigen, fragments, antibodies, or encoding nucleic acids. In particular the invention relates to the use of such components in vaccines against canine Babesiosis.

主权项

1. An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide or an immunogenic fragment thereof that is at least 8 amino acids in length; wherein said polypeptide comprises an amino acid sequence having a sequence identity selected from the group consisting of greater than 76% with the amino acid sequence of SEQ ID NO: 1, greater than 68% with the amino acid sequence of SEQ ID NO: 3, or greater than 76% with the amino acid sequence of SEQ ID NO: 1 and greater than 68% with the amino acid sequence of SEQ ID NO: 3; wherein said polypeptide and said immunogenic fragment thereof individually induce an immune response against a canine Babesia parasite; wherein said nucleotide sequence is under the control of a functionally linked heterologous promoter and does not comprise an intron.