Chromatography systems and methods using them

摘要

Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.

主权项

1. A method comprising:
selecting a fluid flow rate to be used in a chromatography system configured to receive a microfluidic device comprising a plurality of ports fluidically coupled to each other through an internal microchannel of the microfluidic device; determining a dimension of a restrictor in the chromatography system comprising the microfluidic device to provide the selected fluid flow rate; and placing the restrictor of determined dimension downstream of the microfluidic device.