Multi-layered structure for drug reservoir and drug eluting stent including the same

摘要

Disclosed is a multi-layered structure for drug reservoir, comprising a first micelle layer for crosslinking and adhesion, comprising a drug, a multi-arm polymer, a phenol derivative, and a dopa derivative and having a one or two-layered structure; a second micelle layer for crosslinking, being stacked on the first micelle layer, comprising a drug, a multi-arm polymer, and a phenol derivative, and having a one or two-layered structure; and a physiologically active material layer, being stacked on the second micelle layer, comprising a physiologically active material, a water-soluble polymer, and a phenol derivative, and having a one or two-layered structure.

主权项

1. A drug eluting stent comprising: a stent body having a surface; and a coating layer having at least three layers disposed over at least a portion of the stent body; wherein the at least three layers of the coating layer comprising:
a first layer disposed over the surface of the stent body, wherein the first layer comprising paclitaxel embedded within at least one layer of crosslinked 4 arm-polypropylene oxide-polyethylene oxide-tyraminedopamine (4 arm-PPO-PEO-TA/DA) conjugates, wherein the crosslinking of the at least one layer of the first layer being formed by reacting the 4 arm-PPO-PEO-TA/DA conjugates with at least one oxidizing agent; a second layer disposed over the first layer, wherein the second layer comprising paclitaxel embedded within at least one layer of crosslinked 4 arm-polypropylene oxide-polyethylene oxide-tyramine (4 arm-PPO-PEO-TA) conjugates, wherein the crosslinking of the at least one layer of the second layer being formed by reacting the 4 arm-PPO-PEO-TA conjugates with at least one oxidizing agent; wherein the first layer and the second layer being joined together with crosslinkings formed by reacting at least one oxidizing agent with the tyramine/dopamine attached to the 4 arm-PPO-PEO-TA/DA conjugates of the first layer and the tyramine attached to the 4 arm-PPO-PEO-TA conjugates of the second layer; and a third layer disposed over the second layer, wherein the said third layer comprising a crosslinked heparin-polyethylene glycol-tyramine (heparin-PEG-TA) conjugates, wherein the crosslinking of the third layer being formed by reacting the heparin-PEG-TA conjugates with at least one oxidizing agent; wherein the second layer and the third layer being joined together with crosslinkings formed by reacting at least one oxidizing agent with the tyramine attached to the 4arm-PPO-PEO-TA conjugates of the second layer and the tyramine attached to the heparin-PEG-TA conjugates of the third layer.