发明名称 |
METHOD OF SCREENING COMPOUNDS FOR USE IN INHIBITING DEPDC1 - ZNF224 BINDING |
摘要 |
The present invention provides therapeutic agents and methods for treating cancer using the polypeptides composed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. Furthermore, the present invention provides methods of screening for therapeutic agents or compounds useful in inhibition of the DEPDC1/ZN-F224 complex formation or the treatment of cancer. The present invention also provides siRNAs targeting the ZNF224 gene, which are suggested to be useful in the treatment of bladder cancer. |
申请公布号 |
EP2362904(B1) |
申请公布日期 |
2016.11.16 |
申请号 |
EP20090809506 |
申请日期 |
2009.08.21 |
申请人 |
ONCOTHERAPY SCIENCE, INC. |
发明人 |
NAKAMURA, YUSUKE;KATAGIRI, TOYOMASA;TOGASHI, AKIRA |
分类号 |
C12N15/09;A61K38/00;A61P35/00;C07K14/82;C07K19/00;C12N15/113;G01N33/50;G01N33/574 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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