Process for the preparation of tetralone imines for the preparation of active pharmaceutical compounds

摘要

4-(3,4-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene-methylamine and related analogs are prepared from alpha -tetralone by a facile three-step process. This compound is the required intermediate to prepare sertraline, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine. Sertraline has selective serotonin uptake inhibitor activity making it a valuable antidepressant pharmaceutical product.