发明名称 |
Recombinant HCV E2 glycoprotein |
摘要 |
The invention provides modified hepatitis C virus (HCV) E2 glycoproteins comprising the HCV-E2 receptor-binding domain (RBD) including the HVR1, HVR2 and igVR variable regions wherein in at least one of said variable regions at least a part of the variable region is replaced with a flexible linker sequence. The invention also provides vaccine compositions comprising the modified glycoproteins as well as methods of use thereof. |
申请公布号 |
AU2007288129(A1) |
申请公布日期 |
2008.02.28 |
申请号 |
AU20070288129 |
申请日期 |
2007.08.24 |
申请人 |
THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LIMITED |
发明人 |
PANTELIS POUMBOURIOS;HEIDI DRUMMER;KATHLEEN MC CAFFREY |
分类号 |
C07K14/18;A61K38/02;A61K39/29;A61K39/42;A61P31/14;C07K1/36;C07K16/08;C12P21/08 |
主分类号 |
C07K14/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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